MULTI-DRUG RESISTANT ESCHERICHIA COLI AND THEIR SENSITIVITY TO ORAL FOSFOMYCIN IN URINARY TRACT INFECTIONS: A SINGLE-CENTER EXPERIENCE

Objectives: To determine the frequency of Escherichia coli (E. Coli) with multi-drug resistance and sensitivity to oral Fosfomycin in urinary tract infections a public sector hospital Peshawar Pakistan. Material Methods: A descriptive cross-sectional study convenient consecutive sampling technique at Department Medicine Khyber Teaching Hospital Peshawar. total 179 patients were recruited current study. Detailed history examination carried out followed by routine baseline investigations. Under rigorous aseptic settings, two clean midstream urine samples from exhibiting symptoms infection collected. These then promptly transferred laboratory for evaluation E.Coli inoculation on culture media. Once was detected, it tested antibiotic against antibiotics mentioned. The resistant (MDR) strains isolated their checked fosfomycin. All variables data recorded SPSS version 20. Descriptive inferential statistics will be utilized elaborate findings. Results: mean age this 37 years standard deviation ±11.27.Seventy-three (41%) males 106 (59%) females. One hundred eleven (62%) had multidrug-resistant among which sensitive 108(97%) 3(3%) presenting infection. Conclusion: E. are common our setup. However, fosfomycin has documented these MDR majority UTI cases. Keywords: Multidrug-resistant coli, Drug Sensitivity, Fosfomycin,